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PMMA material introduction

Polymethyl methacrylate (PMMA) is a polymer obtained from acrylic acid and its ester polymers and is collectively referred to as acrylic resin.

Test items Test result Test conclusion
Cytotoxicity test Test results
  Proliferation rate Reflect level
Negative control 105.0% 0
Positive control 5.7% 4
Leaching solution 86.8% 1
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Subchronic systemic toxicity test test results:
Clinical observation: Clinical toxicity symptoms (local and systemic) were observed in all test animals.
Visual observation: There were no abnormal changes in the main cavity of the heart, lung, spleen, adrenal gland, intestine, and gonads of the control group.
Histopathological observation: Compared with the control group, there were no obvious pathological changes in 39 organs such as heart, liver, spleen, lung and kidney in the test group.
Hematology examination: Among the 12 blood routine indexes, compared with the control group, there was no statistical difference in the indexes of the test group. Among the 22 blood routine indicators, compared with the control group, the white ball ratio of the test group increased, but there was no obvious biological significance. There was no statistical difference in other indexes of the test article group.
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Bone implantation week (1, 4, 12, 26 weeks) Histological observation
  Sample group Control group Difference Degree of stimulation
  Average score Average score    
1 week 14.1 9.6 4.5 Slight irritation
4 weeks 1.8 1.2 0.6 No stimulation
12 weeks 0.5 0.7 0.2 No stimulation
26 weeks 0.5 0.5 0.0 No stimulation
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Test results The inspected items of the tested samples meet the requirements of the Italian Tecres S.p.A. company bone cement YZB/IT-TEC01-46-2010 standard.  

Comparison of various repair materials

  PMMA Hydroxyapatite Polyetheretherketone Titanium mesh
Ductility High Low Low Low
Mechanical strength High Low High High
Histocompatibility High High High Low
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